EFFECTIVENESS AND SAFETY OF CHINESE MEDICINE FOR HYPERTENSION PATIENTS AFTER menopause: SYSTEMATIC REGISTRATION

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– Blood pressure increases as you get older, and women show higher blood pressure after the age of 60.- High blood pressure affects women less than men before age 50, but the prevalence of high blood pressure in postmenopausal women increases rapidly. postmenopausal women with postmenopausal hypertension

– Risk factors such as increased blood pressure in postmenopausal women – systolic blood pressure due to discontinuation of endogenous estrogen production after aging and menopause – decreased estrogen, endothelial function, reduced salt sensitivity, regular exercise, and menopausal metabolic syndrome.- It has been found that estrogen decreases and causes arteriosclerosis, vascular aging, obesity, insulin sensitivity and dyslipidemia.- The effects of hormone replacement therapy on blood pressure control are not consistent yet, and there is a risk of breast cancer and endocrine cancer.Chinese medicine

Traditional Chinese medicine – lowers blood pressure and its variability, BPV.- To reduce levels of catecholamine, neuropeptide and neurotensin.- It is effective in preventing cardiovascular diseases such as Lenin-angiotensin-aldosterone inhibition-serum estradiol level upward regulation-FSH and LH level downward regulation

– A study was published by JAMA in June 2016 that herbal medicine has a positive effect on menopause symptoms.

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– The primary evaluation index is BP, SBP, dynamic blood pressure DBP, BPV, categorical BP2 after menopause symptoms, quality of life and hormone levels (estradiol, FSH, LH, progesterone, sterone) in the control group

– 39RCT, 3823 patients included.- In all studies, oriental medicine and antihypertensive drugs are combined in the arbitration group, and antihypertensive drugs are treated in the control group.- The most frequently used formulations were Er-xian decoration: Curculigo orchioides Gaertn., Epimedium brevicornu Maxim., Morinda occinalis How, Jimo Anemarrhena asphodeloids Bge., Yellow and White Phellodenselodensiscellodens

CHEMICAL STRUCTURE OF MAIN COMPONENT OF DIZENYU AND MIXED FAT SUL

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DBPDBPCPAD: herbal medicine + antihypertensive agent, AD: antihypertensive agent funnel plot- Mild publishing bias 론결- The combination of herbal medicine and antihypertensive drugs has advantages in improving BP, BPV, postmenopausal symptoms, quality of life, and hormone levels in women with high blood pressure during menopause compared to using only antihypertensive drugs.References- – Xiong, Xingjiang et al. “Effectiveness and Safety of Chinese Medicine in Patients with Postmenopausal Hypertension: Systematic Review and Meta Analysis” Pharmacological Study 141 (2019): 481-500.- – Xiong, Xingjiang et al. “Effectiveness and Safety of Chinese Medicine in Patients with Postmenopausal Hypertension: Systematic Review and Meta Analysis” Pharmacological Study 141 (2019): 481-500.

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